He says claims of a chemical attack were fabricated and "can't serve as a pretext for any forceful actions".
The WHO cited reports that 70 people had been killed.
The World Health Organization said about 500 patients showed signs of exposure to toxic chemicals following the Douma attack. Wednesday's statement is also notable because Trump has criticized his predecessors for publicly telegraphing U.S. military action.
A day earlier, May had said Britain was still assessing who was responsible.
The WHO demanded "immediate unhindered access to the area" and said it was on standby to provide assistance to those affected, as soon as access was granted.
The estimates of how many people died in the suspected chemical attack range from 42 to more than 60 people.
"Syria is keen on cooperating with the OPCW to uncover the truth behind the allegations that some Western sides have been advertising to justify their aggressive intentions", Syria's state news agency SANA said.
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He added, however, that the USA would be unlikely to warn Russian Federation of the coming strike this time.
Trump remains engaged in intensive consultations with United States partners, principally French President Emmanuel Macron and British Prime Minister Theresa May, on a coordinated response to the attack.
Trump's secretary of defense, James Mattis, said on Wednesday that the United States was still assessing what exactly happened in Douma. But Damascus allies had confirmed that precautionary measures were being taken throughout Syria.
BEIRUT (AP) - With a mix of fear and defiance, Syrians braced on Wednesday for a possible USA attack in retaliation to an alleged chemical assault that killed dozens over the weekend. However, US officials and media appear to be focused on some war victims, while turning a blind eye on victims of campaigns the American military took part in, be it in Syria's Raqqa or Iraq's Mosul.
An unconstitutional strike is an impeachable offense and the War Powers Resolution allows any House member to force a floor vote to remove USA troops an illegal military action in Syria.
Six Council members - Bolivia, China, Ethiopia, Equatorial Guinea, Kazakhstan and Russian Federation voted in favour of the draft while seven against (France, the Netherlands, Peru, Poland, Sweden, United Kingdom and United States) and two abstentions (Cote d'Ivoire and Kuwait). Neighboring Turkey, the U.S., the U.K., France, Germany and have blamed Assad regime for the attack, which is denied by Russian Federation and the regime.
Moscow and Washington stymied attempts by each other at the United Nations Security Council on Tuesday to set up worldwide investigations into chemical weapons attacks in Syria. "It's a miscalculation. Any clash between Russian and US militaries will expand beyond a local conflict and an escalation will be inevitable". Though he's president of the United States and has vast powers because of his role as commander-in-chief of USA armed forces, such a serious decision should not be left to him alone.
USA envoy Nikki Haley responded by calling the vote a "travesty". "History will record that, on this day, Russian Federation chose protecting a monster over the lives of the Syrian people", she said.