The week-long tour is the longest solo global trip she has made without the U.S. president.
Trump's visit to Ghana has inevitably drawn comparisons to that of former president Barack Obama and his wife Michelle in 2009.
She added that it was a "special place".
"Whether it is education, drug addiction, hunger, online safety or bullying, poverty or disease, it is too often children who are hit first, and hardest, across the globe", Melania said in a brief address to a group that included the spouses of foreign leaders last week in NY, when they were in town for the United Nations General Assembly.
Trump also spent about 10 minutes inside the dungeons where slaves were held before walking through the "Door of No Return" to be taken across the Atlantic Ocean.
Trump arrived in Ghana on Tuesday wearing a Manolo Blahnik court shoes and a red and white striped dress by French fashion house Céline, as she was greeted by Ghana's own First Lady, Rebecca Akufo-Addo.
"I will never forget the stories.really, really touching".
She called it "very emotional" and "really something that people should see and experience".
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Mrs. Trump replied that she was "very honored" to be there, accepting a gift of Kente cloth and slippers as a remembrance of the trip.
In Africa, interest in Melania Trump's visit is being watched to see if she can mend fences after her husband's reported comment that the continent contained "shithole" countries.
The Sarakasi crew shall present a creative piece depicting a ghetto kid who rises to fame and a group of children is also listed to entertain her on Friday.
Photographs of the two first ladies featured on the front pages of major newspapers in Ghana while the visit was talked about on morning radio shows.
Melania Trump receives flowers during an arrival ceremony after landing at Kotoka International Airport in Accra October 2, 2018.
Though she arrived clad in her signature stilettos for the event, she later swapped her shoes for more practical flats as she toured the castle; she pulled the same stiletto-swap yesterday while visiting the maternity ward of a hospital.
Melania will also visit Malawi and Egypt.
Greater Accra Regional Hospital was the first stop of the day, where the two first ladies joined ten mothers and their babies.