Earlier in the day, Twitter surged 15 percent in its biggest one-day gain in a year after the social media company easily beat Wall Street's revenue and profit estimates.
The Nasdaq composite lost 151.12 points, or 2.1 percent, to 7,167.21.
Market experts blamed disappointing outlooks in tech company results for stoking jitters over world economic growth and future corporate profitability.
The industrial-skewed Dow Jones index has wiped out all its gains for this year after it dropped 608 points, or 2.4 per cent, to 24,583.
Dow Jones Industrial Average futures slipped 300 points, S&P 500 contracted 40 points, and Nasdaq futures indicate a 186-point drop at the opening bell.
Japan's Nikkei index was down 3.3 percent at opening, shedding more than 700 points, while Hong Kong's Hang Seng index dropped by almost two percent.
The share values of several tech giants all fell on Wednesday, including Facebook (down 5.41 percent), Amazon (down 5.91 percent), Google's parent company Alphabet (down 5.17 percent), AT&T (down 8.08 percent) and Netflix (down 9.4 percent).
The benchmark S&P 500 index in the USA slid more than 1.7%, closing down nearly 10% from its September high. After today's gains, the Dow and S&P 500 are each up about 1 percent for the year.
Japan's Nikkei 225 index swooned 3.7 percent and Hong Kong's Hang Seng index ended 1 percent lower.
Red Sox didn't ask Schilling to participate in ceremony involving 2004 team
Historically, teams that have won the first two games of the World Series have gone on to win the series 84 percent of the time . There's no such thing as a good bases-loaded walk to tie a game, of course, but this one looked especially bad.
The S&P 500 lost 46 points, or 1.7 percent, to 2,658.
The S&P 500 is down 17.51 points, or 0.7 percent.
Brent crude, the benchmark for worldwide oil prices, dropped 0.5 percent to $76.52 a barrel in London. Heating oil added 1.2 percent to $2.28 a gallon and natural gas gained 1.1 percent to $3.20 per 1,000 cubic feet.
The Russell 2000 is down 66.81 points, or 4.4 percent. 3M Co slid 5.2 percent after cutting its full-year profit outlook due to currency headwinds. The Nasdaq (.IXIC) jumped 2.95 percent, but remained down 10 percent from its August record high close. The Dow Jones Industrial Average fell more than 300 points in trading Friday, while the S&P 500 dropped almost 2 percent and entered correction territory.
US bond prices edged lower. Netflix gave back 9.4 percent and Amazon dropped 5.9 percent. UPS fell 3 percent.
Bond prices rose. The yield on the 10-year Treasury note fell to 3.13 percent. Bond prices continued to rise, sending yields lower, as traders sought safe-haven investments.
"What makes the latest volatility more troubling is that it's been hard to identify one specific cause", Kerry Craig, global markets strategist at JPMorgan Asset Management, told Bloomberg. The Kospi in South Korea dropped 1.6 percent. Brent crude, the benchmark for worldwide oil prices, added 0.9 percent to close at $77.62 a barrel in London.
CURRENCIES: The dollar fell to 111.99 yen from 112.61 yen on Thursday.